Cyclin D1 (G1-Cyclin & Mantle Cell Lymphoma Marker) Antibody, Clone: [CCND1/12039], Mouse, Monoclonal

Product Overview

• Article Name: Cyclin D1 (G1-Cyclin & Mantle Cell Lymphoma Marker) Antibody, Clone: [CCND1/12039], Mouse, Monoclonal
• Biozol Catalog Number: NBT-595-MSM18-P1ABX
• Supplier Catalog Number: 595-MSM18-P1ABX
• Alternative Catalog Number: NBT-595-MSM18-P1ABX-100
• Manufacturer: NeoBiotechnologies
• Host: Mouse
• Category: Antikörper
• Application: IHC
• Species Reactivity: Human
• Immunogen: Recombinant fragment (around aa100-295) of Cyclin D1 protein (exact sequence is proprietary)
• Alternative Names: B cell CLL/lymphoma 1, B cell leukemia 1, B-cell lymphoma 1 protein, BCL-1 oncogene, CCND1 protein, CCND1/FSTL3 fusion gene, CCND1/IGHG1 fusion gene CCND1/IGLC1 fusion gene, CCND1/PTH fusion gene, G1/S-specific cyclin-D1, Parathyroid adenomatosis 1, PRAD1 oncogene

Product Description

Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11, 14)(q13, q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.

Product Properties

• Clonality: Monoclonal
• Clone Designation: [CCND1/12039]
• Molecular Weight: 36kDa
• NCBI: 595
• UniProt: P24385
• Form: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Images

SDS-PAGE Analysis of Purified Cyclin D1 Mouse Monoclonal Antibody (CCND1/12039). Confirmation of Purity and Integrity of Antibody.

Formalin-fixed, paraffin-embedded human thyroid stained with Cyclin D1 Mouse Monoclonal Antibody (CCND1/12039). Inset: PBS instead of primary antibody, secondary only negative control.