Recombinant fragment corresponding to cytoplasmic domain of human ROS1 protein
Alternative Names:
c ros oncogene 1 receptor tyrosine kinase, MCF3, Oncogene ROS, Proto oncogene tyrosine protein kinase ROS precursor, Proto-oncogene c-Ros-1, Receptor tyrosine kinase c ros oncogene 1, ROS proto oncogene 1, receptor tyrosine kinase, ROS1C, Transmembrane tyrosine specific protein kinase, v ros UR2 sarcoma virus oncogene homolog 1
ROS1, an orphan receptor tyrosine kinase of the insulin receptor family, was initially identified as a homolog of v-ros from the UR2 sarcoma virus. ROS1 consists of a large extracellular domain that is composed of six fibronectin repeats, a transmembrane domain, and an intracellular kinase domain. While the function of ROS1 is undefined, it has been shown to play an important role in differentiation of epididymal epithelium. The first oncogenic fusion of ROS1, FIG-ROS1, was initially identified by research studies in glioblastoma. Investigators have found additional oncogenic ROS1 fusion proteins in NSCLC (at a frequency of ~1.6%), where the ROS1 kinase domain is fused to the amino-terminal region of a number of different proteins, including CD74 and SLC34A2.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
