Macrophage L1 Protein Antibody, IgG1, Clone: [SPM281], Mouse, Monoclonal

Product Overview

• Article Name: Macrophage L1 Protein Antibody, IgG1, Clone: [SPM281], Mouse, Monoclonal
• Biozol Catalog Number: NBT-6279-MSM1X-P1
• Supplier Catalog Number: 6279-MSM1X-P1
• Alternative Catalog Number: NBT-6279-MSM1X-P1-100
• Manufacturer: NeoBiotechnologies
• Host: Mouse
• Category: Antikörper
• Application: FC, IF, IHC
• Species Reactivity: Bovine, Canine, Equine, Feline, Goat, Guinea pig, Human, Monkey, Mouse, Porcine, Primate, Rabbit, Rat
• Immunogen: Affinity Purified monocyte membrane preparation
• Alternative Names: 60B8AG, Calgranulin A (CAGA), Calgranulin B (CAGB), Calprotectin L1L subunit, Chemotactic cytokine CP-10, Cystic fibrosis antigen (CFAG), Leukocyte L1 complex light chain, L1Ag, Macrophage L1 protein Calprotectin, Migration inhibitory factor related protein 8, Myeloid-related protein 8 (MRP-8 or P8), Myeloid-related protein 14 (MRP-14 or P14), Neutrophil cytosolic 7kDa protein, NIF, p8, Migration inhibitory factor related protein 14, S100 calcium binding protein A8 (S100A8), S100 calcium binding protein A9 (S100A9), S100A8/S100A9 complex, MA387, Pro-inflammatory S100 cytokine, Urinary stone protein band A

Product Description

Recognizes the L1 or Calprotectin molecule, an intra-cytoplasmic antigen comprising of a 12kDa alpha chain and a 14kDa beta chain expressed by granulocytes, monocytes and by tissue macrophages. Macrophages usually arise from hematopoietic stem cells in the bone marrow. Under migration into tissues, the monocytes undergo further differentiation to become multifunctional tissue macrophages. They are classified into normal and inflammatory macrophages. Normal macrophages include macrophages in connective tissue (histiocytes), liver (Kupffers cells), lung (alveolar macrophages), lymph nodes (free and fixed macrophages), spleen (free and fixed macrophages), bone marrow (fixed macrophages), serous fluids (pleural and peritoneal macrophages), skin (histiocytes, Langerhanss cell) and in other tissues. Inflammatory macrophages are present in various exudates. Macrophages are part of the innate immune system, recognizing, engulfing and destroying many potential pathogens including bacteria, pathogenic protozoa, fungi and helminthes. This MAb reacts with neutrophils, monocytes, macrophages, and squamous mucosal epithelia and has been shown as an important marker for identifying macrophages in tissue sections.

Product Properties

• Clonality: Monoclonal
• Clone Designation: [SPM281]
• Molecular Weight: 12-14kDa (doublet)
• Isotype: IgG1
• NCBI: 6279
• UniProt: P05109
• Form: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Images

Formalin-fixed, paraffin-embedded human Tonsil stained with Macrophage L1 Protein Monoclonal Antibody (SPM281)