SATB1 (Marker of Lymph Node Metastasis of CRC) Antibody, Clone: [PCRP-SATB1-2C3], Mouse, Monoclonal

Product Overview

• Article Name: SATB1 (Marker of Lymph Node Metastasis of CRC) Antibody, Clone: [PCRP-SATB1-2C3], Mouse, Monoclonal
• Biozol Catalog Number: NBT-6304-MSM6-P0
• Supplier Catalog Number: 6304-MSM6-P0
• Alternative Catalog Number: NBT-6304-MSM6-P0-20
• Manufacturer: NeoBiotechnologies
• Host: Mouse
• Category: Antikörper
• Application: FC, IF
• Species Reactivity: Human
• Immunogen: Recombinant full-length human SATB1 protein
• Alternative Names: DNA-binding protein SATB1, SATB family member 1, SATB homeobox 1, SATB1, Special AT-rich sequence-binding protein 1

Product Description

The homeoproteins CCAAT displacement protein (CDP) and special AT-rich sequence binding protein 1 (SATB1) are transcriptional repressors of many cellular genes, and they participate in cell development and cell type differentiation. SATB1 is expressed primarily in thymocytes, and, like CDP, it also contains a distinct homeobox DNA-binding domain that is essential for DNA binding. SATB1 and CDP interact through these homeodomains and synergistically function as mediators of gene expression. SATB1 contains an additional domain that has a higher affinity for DNA and specifically facilitates the direct association between SATB1 and the nuclear matrix attachment regions (MARs) of DNA. MARs are specific DNA sequences that bind to the nuclear matrix and form the base of chromosomal loops that organize the chromosomes and regulate DNA transcription and replication within the nucleus. The association of SATB1 with the core unwinding element within the base-unpairing region of MARs requires both the MAR and homeobox binding domains of SATB1.

Product Properties

• Clonality: Monoclonal
• Clone Designation: [PCRP-SATB1-2C3]
• Molecular Weight: 115kDa
• NCBI: 6304
• UniProt: Q01826
• Form: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Images

Flow cytometric analysis of PFA-fixed HeLa cells. SATB1 Mouse Monoclonal Antibody (PCRP-SATB1-2C3) followed by goat anti-mouse IgG-CF488 (blue), unstained cells (red).

SDS-PAGE Analysis of Purified SATB1 Mouse Monoclonal Antibody (PCRP-SATB1-2C3). Confirmation of Purity and Integrity of Antibody.

Immunofluorescence Analysis of PFA-fixed HeLa cells stained using SATB1 Mouse Monoclonal Antibody (PCRP-SATB1-2C3) followed by goat anti-mouse IgG-CF488. Membrane stained with phalloidin.