Recognizes a protein of 55kDa, which is identified as GLUT-1. Glucose transporters are integral membrane glycoproteins involved in transporting glucose into most cells. There are many types of glucose transport carrier proteins, designated as Glut-1 to Glut-12. Glut-1 is a major glucose transporter in the mammalian blood-brain barrier. It is expressed in high density on the membranes of human erythrocytes and the brain capillaries that comprise the blood-brain barrier. Glut-1 is expressed at variable levels in many human tissues. Overexpression of Glut-1 has been linked to tumor progression or poor survival of patients with carcinomas of the colon, breast, cervical, lung, bladder and mesothelioma. Glut-1 is a sensitive and specific marker for the differentiation of malignant mesothelioma (positive) from reactive mesothelium (negative).
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Formalin-fixed, paraffin-embedded human ovarian carcinoma stained with GLUT-1 Mouse Monoclonal Antibody (GLUT1/7308). Inset: PBS instead of primary antibody, secondary only negative control.
Formalin-fixed, paraffin-embedded human esophagus stained with GLUT-1 Mouse Monoclonal Antibody (GLUT1/7308). Inset: PBS instead of primary antibody, secondary only negative control.
SDS-PAGE Analysis of Purified GLUT-1 Mouse Monoclonal Antibody (GLUT1/7308). Confirmation of Purity and Integrity of Antibody.
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