Recombinant fragment of mouse BAF47 protein (around aa257-359) (exact sequence is proprietary)
Alternative Names:
BRG1-associated factor 47 (BAF47), hSNF5, Malignant rhabdoid tumor suppressor, RDT, RTPS1, Sfh1p, Snr1, Sucrose nonfermenting yeast homolog like 1, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1, SWI10, Transcription factor TYE4, Transcription regulatory protein SNF5
The INI-1 gene, which encodes a functionally uncharacterized protein component of the hSWI/SNF chromatin remodeling complex, is often mutated or deleted in malignant rhabdoid tumor (MRT). Two isoforms of INI-1, that differ by the variable inclusion of amino acids, potentially are produced by differential RNA splicing. The morphology of MRTs can present challenges in differential diagnosis. The overall survival of MRTs relative to its potential mimics (medulloblastoma, supratentorial primitive neuroectodermal tumors (sPNETs) is quite low, and thus differentiation from these other tumors is desirable. Lack of nuclear labeling by anti-INI-1 is characteristic of MRT. The majority of medulloblastomas and sPNETs are labeled by anti-INI-1. MRTs also originate from the kidney and soft tissues.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Formalin-fixed, paraffin-embedde
Formalin-fixed, paraffin-embedded human epithelioid sarcoma stained with INI-1 Recombinant Mouse Monoclonal Antibody (rSMARCB1/4588). Note loss of nuclear expression in tumor cells and retained positivity in normal cells.
