Recombinant fragment (within aa176-305) of human SOX2 protein (exact sequence is proprietary)
Alternative Names:
ANOP3, Delta EF2a, MCOPS3 (Microphthalmia Syndromic type 3), SOX-2, SRY (sex determining region Y) box 2, SRY related HMG box 2, Transcription factor SOX-2, ysb
SOX2 is required for stem cell maintenance in the central nervous system, and it also regulates gene expression in the stomach. SOX2 is necessary for regulating multiple transcription factors that affect Oct 3/4 expression. An essential function of SOX2 is to stabilize embryonic stem cells in a pluripotent state by maintaining the requisite level of Oct 3/4 expression. Reportedly, SOX2 is associated with aggressive phenotypes of breast, head and neck, gastric, colorectal, bladder, and small cell lung cancers. However, SOX2 is expressed in a high percentage of lung squamous cell carcinomas and has been shown to be an independent favorable prognostic marker.
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:
Recombinant Monoclonal Antibody
Application Notes:
Immunohistochemistry (Formalin-fixed, Not suitable for frozen tissues) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT fo
Formalin-fixed, paraffin-embedded human cervix stained with SOX2 Recombinant Mouse Monoclonal Antibody (rSOX2/1791).
SDS-PAGE Analysis of Purified SOX2 Recombinant Mouse Monoclonal Antibody (rSOX2/1791). Confirmation of Purity and Integrity of Antibody.
Western Blot Analysis of NCCIT cell lysate using SOX2 Recombinant Mouse Monoclonal Antibody (rSOX2/1791).
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