Recombinant fragment (within aa176-305) of human SOX2 protein (exact sequence is proprietary)
Alternative Names:
ANOP3, Delta EF2a, MCOPS3 (Microphthalmia Syndromic type 3), SOX-2, SRY (sex determining region Y) box 2, SRY related HMG box 2, Transcription factor SOX-2, ysb
SOX2 is required for stem cell maintenance in the central nervous system, and it also regulates gene expression in the stomach. SOX2 is necessary for regulating multiple transcription factors that affect Oct 3/4 expression. An essential function of SOX2 is to stabilize embryonic stem cells in a pluripotent state by maintaining the requisite level of Oct 3/4 expression. Reportedly, SOX2 is associated with aggressive phenotypes of breast, head and neck, gastric, colorectal, bladder, and small cell lung cancers. However, SOX2 is expressed in a high percentage of lung squamous cell carcinomas and has been shown to be an independent favorable prognostic marker.
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Formalin-fixed, paraffin-embedded human cervical carcinoma stained with SOX2 Recombinant Rabbit Monoclonal Antibody (SOX2/3811R).
Formalin-fixed, paraffin-embedded human cervical carcinoma stained with SOX2 Recombinant Rabbit Monoclonal Antibody (SOX2/3811R).
Western Blot Analysis of NCCIT cell lysate using SOX2 Recombinant Rabbit Monoclonal Antibody (SOX2/3811R).
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