Recombinant fragment (around aa300-400) of human SOX11 protein
Alternative Names:
SOX11, SRY (sex determining region Y) box 11, SRY related HMG box gene 11, Transcription factor SOX-11
Recognizes a protein of ~47kDa, identified as SOX11. This MAb is highly specific and does not cross-react with other members of the SOX-family. Mantle cell lymphoma (MCL) accounts for 5% to 10% of mature B-cell neoplasms and is an aggressive disease genetically characterized by overexpression of Cyclin D1. Cyclin D1 overexpression is the hallmark of MCL. However, approximately 5%-10% of MCLs lack Cyclin D1 expression and may be misdiagnosed. Almost all Cyclin D1-positive as well as Cyclin D1-negative MCL, show overexpression of SOX-11. The detection of this transcription factor is a useful biomarker for identifying true cyclin D1-negative MCL.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Formalin-fixed, paraffin-embedded human cervical carcinoma stained with SOX11 Recombinant Rabbit Monoclonal Antibody (SOX11/3235R).
Formalin-fixed, paraffin-embedded human mantle cell lymphoma stained with SOX11 Recombinant Rabbit Monoclonal Antibody (SOX11/3235R).
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