SREBP1 (Transcription Factor) Antibody, IgG1, Clone: [SREBP1/1578], Mouse, Monoclonal

Product Overview

• Article Name: SREBP1 (Transcription Factor) Antibody, IgG1, Clone: [SREBP1/1578], Mouse, Monoclonal
• Biozol Catalog Number: NBT-6720-MSM1-P0
• Supplier Catalog Number: 6720-MSM1-P0
• Alternative Catalog Number: NBT-6720-MSM1-P0-20,NBT-6720-MSM1-P0-100
• Manufacturer: NeoBiotechnologies
• Host: Mouse
• Category: Antikörper
• Application: IHC
• Species Reactivity: Human
• Immunogen: Recombinant full-length human SREBP1 protein
• Alternative Names: ADD 1, bHLHd1, Class D basic helix-loop-helix protein 1, Processed sterol regulatory element-binding protein 1, SREBF1, SREBP1c, SREBP-1, Sterol Regulatory Element Binding Transcription Factor 1 / Protein 1, Sterol regulatory element binding transcription factor 1, Sterol regulatory element-binding transcription factor 1

Product Description

The low density lipoprotein (LDL) receptor mediates the endocytic uptake of cholesterol-carrying lipoproteins, thereby controlling cholesterol levels in cells and plasma. Transcription of the LDL receptor gene is controlled by a ten base pair sequence in the 5 flanking region, designated sterol regulatory element 1 (SRE-1). When cellular sterol stores are depleted, the element is activated, the gene is transcribed and the cellular uptake of LDL increases. A set of SREbinding proteins (SREBPs) have been identified, including two basic helixloop-helix-leucine zipper (bHLH-zip) transcription factors, designated SREBP-1 and SREBP-2. SREBP-1 and SREBP-2 have been shown to have the same specificity for SRE-1 in vitro and to activate the transcription of reporter genes containing SRE-1 in the same way.

Product Properties

• Clonality: Monoclonal
• Clone Designation: [SREBP1/1578]
• Molecular Weight: 68/125kDa mature/precursor
• Isotype: IgG1
• NCBI: 6720
• UniProt: P36956
• Form: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Antibody Type: Monoclonal Antibody

Application Notes

• Application Notes: Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 &degC followed by cooling at RT for 20 minutes),Optimal diluti

Images

SDS-PAGE Analysis of Purified SREBP1 Mouse Monoc

IHC analysis of formalin-fixed, paraffin-embedded human ovarian carcinoma. SREBP1 Mouse Monoclonal Antibody (SREBP1/1578) at 2ug/ml. Inset: PBS instead of primary antibody, secondary only negative control.

SDS-PAGE Analysis of Purified SREBP1 Mouse Monoclonal Antibody (SREBP1/1578). Confirmation of Integrity and Purity of Antibody.