Tal1 Antibody, IgG1, Clone: [TAL1/3146], Mouse, Monoclonal

Product Overview

• Article Name: Tal1 Antibody, IgG1, Clone: [TAL1/3146], Mouse, Monoclonal
• Biozol Catalog Number: NBT-6886-MSM3-P1
• Supplier Catalog Number: 6886-MSM3-P1
• Alternative Catalog Number: NBT-6886-MSM3-P1-100
• Manufacturer: NeoBiotechnologies
• Host: Mouse
• Category: Antikörper
• Application: ELISA
• Species Reactivity: Human
• Immunogen: Recombinant human full-length TAL1 protein
• Alternative Names: bHLHa17, Class A basic helix-loop-helix protein 17, OTTHUMP00000009563, OTTHUMP00000009564, SCL, STEM CELL LEUKEMIA HEMATOPOIETIC TRANSCRIPTION FACTOR, Stem cell protein, T cell acute lymphocytic leukemia 1, T cell acute lymphocytic leukemia 1 protein, T cell acute lymphocytic leukemia 1 protein, T cell leukemia/lymphoma 5 protein, T-cell acute lymphocytic leukemia protein 1, T-cell leukemia/lymphoma protein 5, Tal 1 product, TAL 1 protein, TAL bHLH transcription factor 1 erythroid differentiation factor, TAL-1

Product Description

Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase II, a serine/threonine protein kinase known to modulate the activity of other HLH transcription factors.

Product Properties

• Clonality: Monoclonal
• Clone Designation: [TAL1/3146]
• Molecular Weight: 42kDa
• Isotype: IgG1
• NCBI: 6886
• UniProt: P17542
• Form: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.