Recombinant fragment (around aa1431-1531) of human Topo II alpha (TOP2A) protein (exact sequence is proprietary)
Alternative Names:
ATP hydrolyzing DNA topoisomerase II alfa, DNA gyrase, DNA topoisomerase (ATP hydrolyzing), DNA topoisomerase 2 alpha, DNA topoisomerase II 170kD, DNA topoisomerase II alpha, Topoisomerase DNA II alpha 170kDa, TP2A
The topoisomerase II- isoform is a 170kDa nuclear protein and plays an important role in DNA synthesis and RNA transcription, as well as chromosomal segregation during mitosis. Topoisomerase II- is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cells, and has been shown to be over-expressed in many human cancers. Decreased expression of Topoisomerase II- is the predominant mechanism of resistance to several chemotherapeutic agents.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Western Blot Analysis of human A549 cell lysate using Topoisomerase II alpha Recombinant Rabbit Monoclonal Antibody (TOP2A/7169R).
Formalin-fixed, paraffin-embedded human tonsil stained with Topo IIa Recombinant Rabbit Monoclonal Antibody (TOP2A/7169R). Inset: PBS instead of primary antibody, secondary only negative control.
