Recombinant fragment (around aa900-1100) of human TRPS1 protein (exact sequence is proprietary)
Alternative Names:
GC79, LGCR, Transcriptional repressor GATA binding 1, Tricho-rhino-phalangeal syndrome type I protein, Trichorhinophalangeal syndrome I, Trichorhinophalangeal syndrome I homolog, TRPS 1, trpS1, TRPS1 gene, TRPS1_HUMAN, Zinc finger protein GC79, Zinc finger transcription factor TRPS 1 antibody
Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. Ubiquitously expressed in the adult. Found in fetal brain, lung, kidney, liver, spleen and thymus. More highly expressed in androgen-dependent than in androgen-independent prostate cancer cells.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:
Recombinant Monoclonal Antibody
Application Notes:
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes),Optimal dilutio
IHC analysis of formalin-fixed, paraffin-embedded human breast carcinoma. Strong nuclear staining using TRPS1/7912R at 2ug/ml in PBS for 30min RT. HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.
Formalin-fixed, paraffin-embedded human ovary stained with TRPS1 Recombinant Rabbit Monoclonal Antibody (TRPS1/7912R). Inset: PBS instead of primary antibody, secondary only negative control.
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