This MAb reacts with a protein of 20-30kDa, identified as PGP9.5, also known as ubiquitin carboxyl-terminal hydrolase-1 (UchL1). Initially, PGP9.5 expression in normal tissues was reported in neurons and neuroendocrine cells but later it was found in distal renal tubular epithelium, spermatogonia, Leydig cells, oocytes, melanocytes, prostatic secretory epithelium, ejaculatory duct cells, epididymis, mammary epithelial cells, Merkel cells, and dermal fibroblasts. Furthermore, immunostaining for PGP9.5 has been shown in a wide variety of mesenchymal neoplasms as well. A mutation in PGP9.5 gene is believed to cause a form of Parkinsons disease.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Western Blot Analysis of Human Brain, Mouse Brain, Rat Brain, Hamster Brain and Guinea pig Brain tissue lysates using PGP9.5 / UchL1 Recombinant Rabbit Monoclonal Antibody (UCHL1/8107R).
Western blot analysis of human brain tissue lysate using PGP9.5 / UchL1 Recombinant Rabbit Monoclonal Antibody (UCHL1/8107R).
Western Blot Analysis of Human Brain, Human Heart, Human Intestine, Human Kidney, Human Liver, Human Lung, Human Ovary, Human Pancreas, Human Prostrate, Human Skeletal Muscle, Human Skin, Human Spleen, Human Stomach and Human Testis tissue lysates using pgp9.5 Recombinant Rabbit Monoclonal Antibody (UCHL1/8107R).
Formalin-fixed, paraffin-embedded human cerebellum stained with Pgp9.5 Rabbit Recombinant Monoclonal Antibody (UCHL1/8107R). Inset: PBS instead of primary antibody, secondary only negative control.
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