A synthetic peptide, aa260-279 (GASESSYTSVNRGPPLDRAE) of human UPK3A
Alternative Names:
UP3a, UPIIIA, UPK3A, Uroplakin III (UPIII), Uroplakin3A
Uroplakin-3A (UPK3A) is a component of the asymmetric unit membrane (AUM). It is a highly specialized bio-membrane made by terminally differentiated urothelial cells. The protein may play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. UPK3A also contributes to the formation of urothelial glycocalyx, which may play an important role in preventing bacterial adherence through FimH bacterial protein binding leading to bladder infection. UPK3A has been shown as a helpful marker for the detection of bladder cancer.
200ug/ml of Ab Purified from rabbit anti-serum by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.
Application Notes:
Western Blot (1-2ug/ml), Optimal dilution for a specific application should be determined.
Western Blot Analysis in human HEK293 lysate in 1) absence and 2) presence of immunizing peptide using UPK3A Rabbit PAb.
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