Recombinant von Willebrand Factor/ Factor VIII Related-Ag (Endothelial Marker) Antibody, Clone: [VWF/4384R], Rabbit, Monoclonal

Product Overview

• Article Name: Recombinant von Willebrand Factor/ Factor VIII Related-Ag (Endothelial Marker) Antibody, Clone: [VWF/4384R], Rabbit, Monoclonal
• Biozol Catalog Number: NBT-7450-RBM17-P1
• Supplier Catalog Number: 7450-RBM17-P1
• Alternative Catalog Number: NBT-7450-RBM17-P1-100
• Manufacturer: NeoBiotechnologies
• Host: Rabbit
• Category: Antikörper
• Application: IHC
• Species Reactivity: Human
• Immunogen: Recombinant fragment (around aa 1150-1250) of human vWF protein (exact sequence is proprietary)
• Alternative Names: Coagulation Factor VIII, F8VWF, von Willebrand Antigen 2, von Willebrand Disease (vWD)

Product Description

Human von Willebrand factor (VWFor factor VIII-related antigen) is a 309 kDa multimeric plasma glycoprotein, important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Von Willebrand factor also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. Von Willebrand factor is synthesized by endothelial cells and is reported to be expressed in a number of tumors of vascular origin. IHC results aid in the classification of acute myeloid leukemia FAB type M7, angiosarcoma and epithelioid hemangioendothelioma.

Product Properties

• Clonality: Monoclonal
• Clone Designation: [VWF/4384R]
• Molecular Weight: 250kDa
• NCBI: 7450
• UniProt: P04275
• Form: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Images

Formalin-fixed, paraffin-embedded human bone marrow stained with vWFRecombinant Rabbit Monoclonal Antibody (VWF/4384R).