Recombinant von Willebrand Factor / Factor VIII Related-Ag (Endothelial Marker) Antibody, Clone: [VWF/7979R], Rabbit, Monoclonal
Biozol Catalog Number:
NBT-7450-RBM20-P0
Supplier Catalog Number:
7450-RBM20-P0
Alternative Catalog Number:
NBT-7450-RBM20-P0-20,NBT-7450-RBM20-P0-100
Manufacturer:
NeoBiotechnologies
Host:
Rabbit
Category:
Antikörper
Application:
IHC
Species Reactivity:
Human
Immunogen:
Recombinant fragment (around aa 1150-1250) of human vWF protein (exact sequence is proprietary)
Alternative Names:
Coagulation Factor VIII, F8VWF, von Willebrand Antigen 2, von Willebrand Disease (vWD)
Human von Willebrand factor (VWF or factor VIII-related antigen) is a 309 kDa multimeric plasma glycoprotein, important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Von Willebrand factor also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. Von Willebrand factor is synthesized by endothelial cells and is reported to be expressed in a number of tumors of vascular origin. IHC results aid in the classification of acute myeloid leukemia FAB type M7, angiosarcoma and epithelioid hemangioendothelioma.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:
Recombinant Monoclonal Antibody
Application Notes:
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes),Optimal dilutio
