Recombinant von Willebrand Factor / Factor VIII Related-Ag (Endothelial Marker) Antibody, Clone: [MSVA-521R], Rabbit, Monoclonal
Biozol Catalog Number:
NBT-7450-RBM29-P0
Supplier Catalog Number:
7450-RBM29-P0
Alternative Catalog Number:
NBT-7450-RBM29-P0-20
Manufacturer:
NeoBiotechnologies
Host:
Rabbit
Category:
Antikörper
Application:
IHC
Species Reactivity:
Human
Immunogen:
Recombinant fragment of human vWF protein (aa1815-1939) (exact sequence is proprietary)
Alternative Names:
Coagulation Factor VIII, Factor VIII Related Antigen, F8VWF, von Willebrand Antigen 2, von Willebrand Disease (vWD)
von Willebrand Factor (vWF) is a multimeric glycoprotein that is found in endothelial cells, plasma and platelets. It acts as a carrier protein for Factor VIII and promotes platelet adhesion and aggregation. vWF undergoes a variety of posttranslational modifications that influence the affinity and availability for Factor VIII, including cleavage of the propeptide and formation of N-terminal disulfide bonds. This antibody helps to establish the endothelial nature of some lesions of disputed histogenesis, e.g. Kaposis sarcoma and cardiac myxoma. It is widely used for differentiating vascular lesions from those of other tissue differentiation within a panel of other vascular markers although not all tumors of endothelial differentiation contain this antigen.
Ab produced in HEK293 cell mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide.
von Willebrand factor Rabbit Recombinant Monoclonal Antibody (MSVA-521R) tested on many normal and cancer tissues. The immunohistochemistry staining in these tissues aligns with the expression data in Human Protein Atlas.
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