CF1, Delta transcription factor, INO80 complex subunit S, NF E1, NFE1, Transcriptional repressor protein YY1, UCR motif DNA binding protein, UCRBP, Yin and yang 1, Yin and Yang 1 protein, YY-1, YY1 transcription factor
The YY1 transcription factor, also known as NF-E1 (human) and Delta or UCRBP (mouse) is of interest due to its diverse effects on a wide variety of target genes. YY1 is broadly expressed in a wide range of cell types and contains four C-terminal zinc finger motifs of the Cys-Cys-His-His type and an unusual set of structural motifs at its N-terminal end. It binds to downstream elements in several vertebrate ribosomal protein genes, where it apparently acts positively to stimulate transcription and can act either negatively or positively in the context of the immunoglobulin k 3 enhancer and immunoglobulin heavy-chain OOE1 site as well as the P5 promoter of the adenoassociated virus. It thus appears that YY1 is a bifunctional protein, capable of functioning as an activator in some transcriptional control elements and a repressor in others.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Formalin-fixed, paraffin-embedded human tonsil stained with YY1 Mouse Monoclonal (YY1/5436). Inset: PBS instead of primary antibody, secondary only negative control.
SDS-PAGE Analysis of Purified YY1 Mouse Monoclonal Antibody (YY1/5436). Confirmation of Purity and Integrity of Antibody.
Western blot analysis of Daudi cell lysate using YY1 Mouse Monoclonal (YY1/5436).
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