ARID1A / SMARCF1 Antibody, IgG2b, Clone: [ARID1A/7735], Mouse, Monoclonal

Product Overview

• Article Name: ARID1A / SMARCF1 Antibody, IgG2b, Clone: [ARID1A/7735], Mouse, Monoclonal
• Biozol Catalog Number: NBT-8289-MSM1-P1
• Supplier Catalog Number: 8289-MSM1-P1
• Alternative Catalog Number: NBT-8289-MSM1-P1-100
• Manufacturer: NeoBiotechnologies
• Host: Mouse
• Category: Antikörper
• Application: IHC
• Species Reactivity: Human
• Immunogen: Recombinant fragment (around aa1900-2000) of human ARID1A protein (exact sequence is proprietary)
• Alternative Names: actin-dependent regulator of chromatin subfamily F member 1, ARID domain containing protein 1A, AT rich interactive domain 1A (SWI like), AT rich interactive domain containing protein 1A, B120, BAF250, BAF250A, BM029, brain protein 120, BRG1-associated factor 250a, C1ORF4, chromatin remodeling factor p250, chromosome 1 open reading frame 4, ELD, hELD, hOSA1, matrix-associated, MRD14, OSA1 nuclear protein, P270, SMARCF1, SWI-like protein, SWI/SNF complex protein p270, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily f, member 1

Product Description

The SWI-SNF complex is involved in the activation of transcription via the remodeling of nucleosome structure in an ATP-dependent manner. Brm (also designated SNF2a) and Brg-1 (also designated SNF2b) are the ATPase subunits of the mammalian SWI-SNF complex. Brm, Brg-1, Ini1 (integrase interactor 1, also designated SNF5), BAF155 (also designated SRG3) and BAF170 are thought to comprise the functional core of the SWI-SNF complex. Addition of Ini1, BAF155 and BAF170 to Brg-1 appears to increase remodeling activity. Other complex subunits, such as BAF250a (p270 or ARID1A) and BAF250b (ARID1B), are thought to play regulatory roles.

Product Properties

• Clonality: Monoclonal
• Clone Designation: [ARID1A/7735]
• Molecular Weight: 165-320kDa
• Isotype: IgG2b
• NCBI: 8289
• UniProt: O14497
• Form: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Images

Formalin-fixed, paraffin-embedded human ovarian cancer stained with ARID1A Mouse Monoclonal Antibody (ARID1A/7735). Inset: PBS instead of primary antibody, secondary only negative control.