ABCC11 / ATP Binding Cassette Subfamily C Member 11 Antibody, IgG2b, Clone: [ABCC11/2438], Mouse, Monoclonal
Biozol Catalog Number:
NBT-85320-MSM2-P0
Supplier Catalog Number:
85320-MSM2-P0
Alternative Catalog Number:
NBT-85320-MSM2-P0-20
Manufacturer:
NeoBiotechnologies
Host:
Mouse
Category:
Antikörper
Application:
IHC
Species Reactivity:
Human
Immunogen:
Recombinant fragment (around aa400-600) of human ABCC11 protein (exact sequence is proprietary)
Alternative Names:
ABCC11, ATP binding cassette sub family C (CFTR/MRP) member 11, ATP binding cassette transporter MRP8, ATP binding cassette transporter sub family C member 11, EWWD, MRP8, Multidrug resistance-associated protein 8, WW
ATP-binding cassette (ABC) transporters belong to an evolutionarily conserved family of proteins that catalyze the transport of molecules across extra- and intracellular membranes through the energy of ATP hydrolysis. ABC genes comprise seven subfamilies, designated ABC1, MDR/TAP, MRP, ALD, OABP, GCN20 and White. The complete human ABCC subfamily has 12 identified members (ABCC1-12), nine from the multidrug resistance-like subgroup, two from the sulfonylurea receptor subgroup, and the CFTR gene. The human ABCC11 gene maps to chromosome 16q12.1 and encodes a 1,382 amino acid protein. The human ABCC12 gene maps to chromosome 16q12.1 and encodes a 1,359 amino acid protein. Transcripts of ABCC11 and ABCC12 genes are present in various adult human tissues, including liver, lung and kidney, and also in several fetal tissues. Their chromosomal localization, potential function and expression patterns identify them as candidates for paroxysmal kinesigenic choreoathetosis, a disorder characterized by attacks of involuntary movements and postures, chorea and dystonia. Other inherited disorders where ABC transporters are implicated include cystic fibrosis, neurological disease, retinal degeneration, cholesterol and bile transport defects, anemia and drug response.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
SDS-PAGE Analysis of Purified ABCC11 Mouse Monoclonal Antibody (ABCC11/2438). Confirmation of Purity and Integrity of Antibody.
Formalin-fixed, paraffin-embedded human triple negative breast cancer stained with ABCC11 Mouse Monoclonal Antibody (ABCC11/2438). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.
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