Recombinant fragment (around aa600-800) of human ABCB11 protein (exact sequence is proprietary)
Alternative Names:
ABC member 16, MDR/TAP subfamily, ABC16, ABCB1, Abcb11, ATP binding cassette sub family B (MDR/TAP) member 11, ATP binding cassette sub family B member 11, Bile salt export pump (BSEP), BRIC2, PFIC2, PGY4, progressive familial intrahepatic cholestasis 2, Sister of P glycoprotein, Spgp
ATP-binding cassette (ABC) transporters are an evolutionarily conserved family of proteins that catalyze the transport of molecules across extra- and intracellular membranes through the energy of ATP hydrolysis. ABC genes comprise seven subfamilies, designated ABC1, Mdr/TAP, MRP, ALD, OABP, GCN20 and White. The secretion of bile salt molecules from blood into bile is a major driving force for bile formation. Bile salt export pump (BSEP) is a member of the Mdr/TAP subfamily of ABC transporters that mediates the transport of bile acids across the hepatocyte canalicular membrane and regulates bile acid-dependent bile secretion. BSEP contains putative phosphorylation sites for protein kinase A, protein kinase C (PKC) and Ca2+-calmodulin dependent kinase II, whose regulation may be dependent on bile salt concentration.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
SDS-PAGE Analysis of Purified ABCB11 / BSEP Mouse Monoclonal Antibody (BSEP/7534). Confirmation of Purity and Integrity of Antibody.
Western blot analysis of THP-1 cell lysate using ABCB11 / BSEP Mouse Monoclonal Antibody (BSEP/7534).
