CD7 (T-Cell Leukemia Marker) Antibody, IgG1, Clone: [T3-3A1], Mouse, Monoclonal

Product Overview

• Article Name: CD7 (T-Cell Leukemia Marker) Antibody, IgG1, Clone: [T3-3A1], Mouse, Monoclonal
• Biozol Catalog Number: NBT-924-MSM5-P1
• Supplier Catalog Number: 924-MSM5-P1
• Alternative Catalog Number: NBT-924-MSM5-P1-100
• Manufacturer: NeoBiotechnologies
• Host: Mouse
• Category: Antikörper
• Application: FC, IF
• Species Reactivity: Human
• Immunogen: Human T cells
• Alternative Names: GP40, Leu9, p41, T-cell leukemia antigen, T-cell surface antigen Leu-9, Tp40, TP41

Product Description

Recognizes a protein of 40kDa, identified as CD7, a member of the immunoglobulin gene superfamily. Its N-terminal amino acids 1-107 are highly homologous to Ig kappa-L chains whereas the carboxyl-terminal region of the extracellular domain is proline-rich and has been postulated to form a stalk from which the Ig domain projects. CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia. It is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells. Cross-linking surface CD7 positively modulates T cell and NK cell activity as measured by calcium fluxes, expression of adhesion molecules, cytokine secretion and proliferation. CD7 associates directly with phosphoinositol 3-kinase. CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation.

Product Properties

• Clonality: Monoclonal
• Clone Designation: [T3-3A1]
• Molecular Weight: 40kDa
• Isotype: IgG1
• NCBI: 924
• UniProt: P09564
• Form: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.