CD8A (Cytotoxic / Suppressor T-Cell Marker) Antibody, IgG1, Clone: [T8/209], Mouse, Monoclonal

Product Overview

• Article Name: CD8A (Cytotoxic / Suppressor T-Cell Marker) Antibody, IgG1, Clone: [T8/209], Mouse, Monoclonal
• Biozol Catalog Number: NBT-925-MSM6-P1
• Supplier Catalog Number: 925-MSM6-P1
• Alternative Catalog Number: NBT-925-MSM6-P1-100
• Manufacturer: NeoBiotechnologies
• Host: Mouse
• Category: Antikörper
• Application: ELISA
• Species Reactivity: Human, Primate
• Immunogen: Recombinant human T8 (CD8a) protein
• Alternative Names: CD8 antigen, alpha polypeptide (p32), T8/Leu-2 T-lymphocyte differentiation antigen, Ly3, LYT3, MAL, T-cell surface glycoprotein CD8 alpha chain

Product Description

This MAb is specific for the 32kDa alpha chain of human CD8, known as CD8a or CD8 alpha.CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.

Product Properties

• Clonality: Monoclonal
• Clone Designation: [T8/209]
• Molecular Weight: 32kDa
• Isotype: IgG1
• NCBI: 925
• UniProt: P01732
• Form: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.