CD40 / TNFRSF5 / CD40L-Receptor Antibody, IgG2b, Clone: [C40/2383], Mouse, Monoclonal

Product Overview

• Article Name: CD40 / TNFRSF5 / CD40L-Receptor Antibody, IgG2b, Clone: [C40/2383], Mouse, Monoclonal
• Biozol Catalog Number: NBT-958-MSM3-P1
• Supplier Catalog Number: 958-MSM3-P1
• Alternative Catalog Number: NBT-958-MSM3-P1-100
• Manufacturer: NeoBiotechnologies
• Host: Mouse
• Category: Antikörper
• Application: ELISA, FC, IHC, WB
• Species Reactivity: Human
• Immunogen: Recombinant fragment of human CD40 protein (around aa 29-107) (exact sequence is proprietary)
• Alternative Names: B-cell surface antigen CD40, Bp50, CD40, CD40L receptor, GP39, HIGM1, IGM, IMD3, p50, TBAM, TNF receptor superfamily member 5, TNFRSF5, TRAP

Product Description

CD40 is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is expressed on B-lymphocytes, follicular dendritic cells, bone marrow-derived dendritic cells, thymic epithelium, and interdigitating cells in the T-cell zones of secondary lymphoid organs.

Product Properties

• Clonality: Monoclonal
• Clone Designation: [C40/2383]
• Molecular Weight: 43kDa
• Isotype: IgG2b
• NCBI: 958
• UniProt: P25942
• Form: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Images

Flow Cytometric Analysis of U2OS cells using Mon

Formalin-fixed, paraffin-embedded human tonsil stained with CD40 Mouse Monoclonal Antibody (C40/2383).

Formalin-fixed, paraffin-embedded human tonsil stained with CD40 Mouse Monoclonal Antibody (C40/2383).

Flow Cytometric Analysis of U2OS cells using Monospecific Mouse Monoclonal Antibody to CD40 (C40/2383) followed by goat anti-mouse IgG-CF488 (blue), isotype control (red).

SDS-PAGE Analysis of Purified CD40 Mouse Monoclonal Antibody (C40/2383). Confirmation of Integrity and Purity of Antibody.

Analysis of Protein Array containing more than 19,000 full-length human proteins using Monospecific Mouse Monoclonal Antibody to CD40 (C40/2383). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SDs) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SDs) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

Western blot analysis of Human pancreas, Mouse pancreas, Rat pancreas, Hamster Pancreas, Guinea pig Pancreas and Rabbit Pancreas tissue lysates using Colipase Rabbit Recombinant Monoclonal Antibody (CLPS/12806R).

Western blot analysis of Human pancreas, Mouse pancreas, Rat pancreas, Hamster Pancreas, Guinea pig Pancreas and Rabbit Pancreas tissue lysates using Colipase Rabbit Recombinant Monoclonal Antibody (CLPS/12972R).

Western Blot Analysis of Human Brain tissue lysate using FOLH1 Mouse Monoclonal Antibody (FOLH1/3734)

Western Blot Analysis of Human Brain tissue lysate using FOLH1 Recombinant Rabbit Monoclonal Antibody (FOLH1/9735R)

Western blot analysis of Human Brain, Human Liver, HeLa, Jurkat and Y79 lysates using Glutamine Synthetase Recombinant Rabbit Monoclonal Antibody (GLUL/8996R).

Western Blot Analysis of HT-29 cell lysate using Cytokeratin 20 Recombinant Rabbit Monoclonal Antibody (KRT20/7805R).

Western Blot Analysis of Human Liver, HeLa and K-562 lysates using PSMD4 Mouse Monoclonal Antibody (CPTC-PSMD4-3).

Western Blot Analysis of Raji lysate using CD40 Mouse Monoclonal Antibody (CD40/2383).

Western Blot Analysis of Raji lysate using CD40 Mouse Monoclonal Antibody (C40/2383)