Major Vault Protein (MVP) Antibody, IgG1, Clone: [SPM280], Mouse, Monoclonal

Product Overview

• Article Name: Major Vault Protein (MVP) Antibody, IgG1, Clone: [SPM280], Mouse, Monoclonal
• Biozol Catalog Number: NBT-9961-MSM2X-P1
• Supplier Catalog Number: 9961-MSM2X-P1
• Alternative Catalog Number: NBT-9961-MSM2X-P1-100
• Manufacturer: NeoBiotechnologies
• Host: Mouse
• Category: Antikörper
• Application: FC, IF, IHC
• Species Reactivity: Human
• Immunogen: proteins precipitated from human breast cancer MCF-7 cells
• Alternative Names: Lung resistance-related protein (LRP), Major Vault Protein, MVP, VAULT1

Product Description

Recognizes a protein of 104kDa-110kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for 70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy.

Product Properties

• Clonality: Monoclonal
• Clone Designation: [SPM280]
• Molecular Weight: 104-110kDa
• Isotype: IgG1
• NCBI: 9961
• UniProt: Q14764
• Form: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Images

Formalin-fixed, paraffin-embedded human Testicular Carcinoma stained with MVP Monoclonal Antibody (SPM280).