Recombinant Major Vault Protein (MVP) Antibody, IgG1, Clone: [r1032], Mouse, Monoclonal
Biozol Catalog Number:
NBT-9961-MSM4-P0
Supplier Catalog Number:
9961-MSM4-P0
Alternative Catalog Number:
NBT-9961-MSM4-P0-20
Manufacturer:
NeoBiotechnologies
Host:
Mouse
Category:
Antikörper
Application:
IHC, WB
Species Reactivity:
Human
Immunogen:
Proteins precipitated from human breast cancer MCF-7 cells
Alternative Names:
Lung resistance-related protein (LRP), Major Vault Protein, MVP, VAULT1
Recognizes a protein of 104kDa-110kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Western Blot Analysis of Human Lung, Human Spleen tissue, Human Stomach and A549 lysates using Major Vault Protein Recombinant Rabbit Monoclonal Antibody (r1032).
SDS-PAGE Analysis of Purified MVP Recombinant Mouse Monoclonal Antibody (r1032). Confirmation of Purity and Integrity of Antibody.
Western blot analysis of U-87, A549 & SK-BR3 cell lysate using MVP Recombinant Mouse Monoclonal Antibody (r1032).
Formalin-fixed, paraffin-embedded human prostate stained with MVP Recombinant Mouse Monoclonal Antibody (r1032).
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