Neurofilament (H+L) (Neuronal Marker) Antibody, IgG1, Clone: [RT-97 + NR-4], Mouse, Monoclonal

Product Overview

• Article Name: Neurofilament (H+L) (Neuronal Marker) Antibody, IgG1, Clone: [RT-97 + NR-4], Mouse, Monoclonal
• Biozol Catalog Number: NBT-MSM2-1201-P1
• Supplier Catalog Number: MSM2-1201-P1
• Alternative Catalog Number: NBT-MSM2-1201-P1-100
• Manufacturer: NeoBiotechnologies
• Host: Mouse
• Category: Antikörper
• Application: FC, IHC
• Species Reactivity: Gallus, Human, Mouse, Porcine, Rat
• Immunogen: Triton-X 100 insoluble proteins of rat brain (RT-97), Neurofilaments from porcine spinal cord (NR-4)
• Alternative Names: NEFH, Neurofilament H, Neurofilament Heavy Polypeptide 200kDa, Neurofilament Triplet H Protein, NF-H, NF200. 68kDa neurofilament protein, Light molecular weight neurofilament protein, NEFL, Neurofilament light polypeptide 68kDa, Neurofilament light polypeptide, Neurofilament protein, light chain, Neurofilament subunit NF-L, Neurofilament triplet L protein, NF-L, NF68

Product Description

This MAb reacts with a 200kDa and 68kDa protein, identified as heavy and light sub-units of neurofilaments (NF-H NF-L). Neurofilaments make up the main structural elements of axons and dendrites and are found in neurons, peripheral nerves, and sympathetic ganglion cells. Neurofilaments consist of three major subunits with molecular weights of 68kDa (NF-L), 160kDa (NF-M) and 200kDa (NF-H). Anti-neurofilament stains a number of neural, neuroendocrine, and endocrine tumors. Neuromas, ganglioneuromas, gangliogliomas, ganglioneuroblastomas, and neuroblastomas stain positively for anti-neurofilament. Neurofilaments are also present in paragangliomas as well as adrenal and extra-adrenal pheochromocytomas. Carcinoids, neuroendocrine carcinomas of the skin, and oat cell carcinomas of the lung also express neurofilament.

Product Properties

• Clonality: Monoclonal
• Clone Designation: [RT-97 + NR-4]
• Molecular Weight: 200kDa & 68kDa
• Isotype: IgG1
• NCBI: 4744
• UniProt: P12036
• Form: 200ug/ml of Ab Purified from Bioreactor Concentrate. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Images

Flow Cytometric Analysis of

Formalin-fixed, paraffin-embedded human Cerebellum stained with Neurofilament Monoclonal Antibody (RT-97 + NR-4).

Formalin-fixed, paraffin-embedded Rat Cerebellum stained with Neurofilament Monoclonal Antibody (RT-97 + NR-4).

Flow Cytometric Analysis of HEK293 cells using Neurofilament Monoclonal Antibody (RT-97 + NR-4) followed by goat anti-Mouse IgG-CF488 (Blue), Isotype control (Red).