CD137, Mouse Antibody, IgG2a, Clone: [LOB12], Rat, Monoclonal
Biozol Catalog Number:
NBT-RTM1-2012-P0
Supplier Catalog Number:
RTM1-2012-P0
Alternative Catalog Number:
NBT-RTM1-2012-P0-20,NBT-RTM1-2012-P0-100
Manufacturer:
NeoBiotechnologies
Host:
Rat
Category:
Antikörper
Application:
FC, Functional Studies, IF
Species Reactivity:
Mouse
Immunogen:
Murine CD137 human Fc fusion protein
Alternative Names:
4-1BB ligand receptor, 4-1BB, Mouse, homolog, CD137, HLDA VI, induced by lymphocyte activation (ILA), Interleukin activated receptor homolog of Mouse Ly63, Ly63, Mouse, Receptor protein 4 1BB, T cell antigen ILA, T-cell antigen 4-1BB homolog, T-cell antigen ILA, TNF receptor superfamily member 9, Tumor necrosis factor receptor superfamily member 9 (TNFRSF9)
CD137 (4-1BB), a member of the tumor necrosis factor receptor superfamily, is a type I transmembrane glycoprotein expressed on the cell surface of activated splenic T cells and thymocytes. The functions of CD137 in T lymphocytes include regulating activation, proliferation and apoptosis. CD137 and CD28 are costimulatory molecules of T cell activation. Costimulatory molecules are important in initiating anti-tumor immune responses. CD137 plays an important role in regulating T-cell-dependent immune responses. Expression of CD137 correlates negatively with lymphocyte proliferation and positively with the degree of activation-induced cell death caused by mitogen overstimulation. In monocytes, CD137 induces activation, promotes adherence and prolongs survival. The LOB12.3 antibody is an agonistic antibody that has been shown to stimulate 4-1BB signaling and delay tumor growthin vivowhen administered in combination with immune checkpoint inhibitors.
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:
Monoclonal Antibody
Application Notes:
Functional Studies (Order Antibody without BSA & Azide), Flow Cytometry (0.5-1ug/million cells in 0.1ml), Immunofluorescence (1-2ug/ml), Optimal dilution for a specific application should be determined.
* VAT and and shipping costs not included. Errors and price changes excepted
