Integrins are heterodimers composed of noncovalently associated transmembrane (TM) and A°a subunits. The 16 (TM) and 8 A°a subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors, both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
Clonality:
Monoclonal
Clone Designation:
[AvB6 53a.2]
Molecular Weight:
150-160kDa under non-reducing conditions. Under reducing conditions|cleaved into 2 bands of ~125-130kDa +20-25kDa
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:
Monoclonal Antibody
Application Notes:
ELISA (For coating use Ab at 1-5ug/ml, order Ab without BSA), Immunoprecipitation (1-2ug/500ug protein), ,Flow Cytometry (0.5-1ug/million cells), Immunofluorescence (1-2ug/ml), Western Blot (0.5-1ug/ml),,Optimal dilution for a specific application should
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