This NALP12 antibody was produced from a mouse immunized with NLRP12/NALP12 recombinant protein.
This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Alternatively spliced transcript variants encoding distinct isoforms have been described but the full-length nature of some of these has not been determined.
The stated application concentrations are suggested starting points. Titration of the NALP12 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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