SUMO2/3 Antibody, Rabbit, Polyclonal

Product Overview

• Article Name: SUMO2/3 Antibody, Rabbit, Polyclonal
• Biozol Catalog Number: NSJ-F42562-0.4ML
• Supplier Catalog Number: F42562-0.4ML
• Alternative Catalog Number: NSJ-F42562-0.4ML
• Manufacturer: NSJ Bioreagents
• Host: Rabbit
• Category: Antikörper
• Application: ELISA, IF, IHC, WB
• Species Reactivity: Human, Rat
• Immunogen: This SUMO2/3 antibody recognizes SUMO2 and SUMO3. It was produced from rabbits immunized with a recombinant protein encoding full length human SUMO3.

Product Description

Covalent modification of target lysines by SUMO (small ubiquitin-like modifier) modulates processes such as protein localization, transcription, nuclear transport, mitosis, DNA replication and repair, signal transduction, and viral reproduction. SUMO does not seem to be involved in protein degradation and may in fact function as an antagonist of ubiquitin in the degradation process. The SUMO family consists of SUMO1 and closely related homologs SUMO2, SUMO3, and SUMO4. Sumoylation has been shown to regulate a wide range of proteins, including MDM2, PIAS, PML, RanGAP1, RanBP2, p53, p73, HIPK2, TEL, c-Jun, Fas, Daxx, TNFRI, Topo-I, Topo-II, PARK2, WRN, Sp100, IkB-alpha, Androgen receptor (AR), GLUT1/4, CaMK, DNMT3B, TDG, HIF1A, CHD3, EXOSC9, RAD51, and viral targets such as CMV-IE1/2, EBV-BZLF1, and HPV/BPV-E1.

Product Properties

• Clonality: Polyclonal
• UniProt: P55854
• Purity: Purified
• Form: In 1X PBS, pH 7.4, with 0.09% sodium azide
• Antibody Type: Primary Antibody

Application Notes

• Application Dilute: Immunofluorescence: 1:10-1:50,IHC (Paraffin): 1:50-1:100,Western blot: 1:1000
• Application Notes: Titration of the SUMO2/3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.