A portion of amino acids 50-79 from the human protein was used as the immunogen for this HMGB3 antibody.
HMGB3 belongs to the high mobility group (HMG) protein superfamily. Like HMG1 and HMG2, HMGB3 contains DNA-binding HMG box domains and is classified into the HMG box subfamily. Members of the HMG box subfamily are thought to play a fundamental role in DNA replication, nucleosome assembly and transcription.