A portion of amino acids 155-184 from human IKKA was used as the immunogen for this IKK antibody. This sequence is 100% homologous with human IKKB.
IKKA is a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor.
