This WDR5 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 321-354 amino acids from human WDR5.
Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at Lys-4. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at Lys-4 of histone H3. H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.
