This mouse Hes1 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 205-239 amino acids from the C-terminal region of mouse Hes1.
Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity). Binds DNA on N-box motifs: 5-CACNAG-3 with high affinity and on E-box motifs: 5-CANNTG-3 with low affinity. May play a role in a functional FA core complex response to DNA cross- link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity).
