RTN4 Antibody / Reticulon 4 / Nogo A, Rabbit, Polyclonal
Biozol Catalog Number:
NSJ-F53834-0.05ML
Supplier Catalog Number:
F53834-0.05ML
Alternative Catalog Number:
NSJ-F53834-0.05ML
Manufacturer:
NSJ Bioreagents
Host:
Rabbit
Category:
Antikörper
Application:
WB
Species Reactivity:
Human
Immunogen:
A portion of amino acids 28-58 from the human protein was used as the immunogen for the RTN4 antibody.
Reticulon-4 is a developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing.
