A portion of amino acids 43-75 from the human protein was used as the immunogen for the DEDD2 antibody.
DNA-binding death effector domain-containing protein 2 may play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.
