A portion of amino acids 17-49 from the human protein was used as the immunogen for the Atrogin 1 antibody.
F-box only protein 32 / Atrogin 1 is a substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1.
