Dnmt3a Antibody, Clone: [1823CT281.43.36], Mouse, Monoclonal

Product Overview

• Article Name: Dnmt3a Antibody, Clone: [1823CT281.43.36], Mouse, Monoclonal
• Biozol Catalog Number: NSJ-F54141-0.05ML
• Supplier Catalog Number: F54141-0.05ML
• Alternative Catalog Number: NSJ-F54141-0.05ML
• Manufacturer: NSJ Bioreagents
• Host: Mouse
• Category: Antikörper
• Application: WB
• Species Reactivity: Human
• Immunogen: Recombinant human Dnmt3a was used as the immunogen for the Dnmt3a antibody.

Product Description

Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated Lys-36 of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. [UniProt]

Product Properties

• Clonality: Monoclonal
• Clone Designation: [1823CT281.43.36]
• UniProt: Q9Y6K1
• Purity: Protein G purified
• Form: In 1X PBS, pH 7.4, with 0.09% sodium azide
• Antibody Type: Primary Antibody

Application Notes

• Application Dilute: WB: 1:2000-1:4000
• Application Notes: The stated application concentrations are suggested starting points. Titration of the Dnmt3a antibody may be required due to differences in protocols and secondary/substrate sensitivity.