A portion of amino acids 681-715 from human GRM2 was used as the immunogen for the mGluR2 antibody.
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.
The stated application concentrations are suggested starting points. Titration of the mGluR2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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