A portion of amino acids 140-174 from human IGFBP1 was used as the immunogen for the IGFBP1 antibody.
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
The stated application concentrations are suggested starting points. Titration of the IGFBP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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