A portion of amino acids 442-470 from the human protein were used as the immunogen for the Dishevelled antibody.
DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.
Western blot: 1:1000-1:2000,Immunohistochemistry (FFPE): 1:25-1:50,Immunofluorescence: 1:25
Application Notes:
The stated application concentrations are suggested starting points. Titration of the Dishevelled antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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