A portion of amino acids 18-46 from the human protein were used as the immunogen for the FOLR2 antibody.
FOLR2 is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients.
Western blot: 1:1000,Immunohistochemistry (FFPE): 1:25-1:50
Application Notes:
The stated application concentrations are suggested starting points. Titration of the FOLR2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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