A portion of amino acids 1361-1391 from the human protein were used as the immunogen for the ATP7B antibody.
ATP7B is a member of the P-type cation transport ATPase family and a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile.
Western blot: 1:1000-1:2000,Immunohistochemistry (FFPE): 1:25-1:50,Immunofluorescence: 1:25
Application Notes:
The stated application concentrations are suggested starting points. Titration of the ATP7B antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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