A portion of amino acids 51-79 from the human protein was used as the immunogen for the BAX antibody.
Apoptosis is a highly regulated process that is essential for the development and maintenance of multicellular organisms. The BAX protein is a crucial regulator of apoptosis, promoting cell death by permeabilizing the mitochondrial outer membrane and initiating the release of cytochrome c, which triggers a cascade of events leading to cell death. With its ability to induce apoptosis, the BAX protein acts as a safeguard against abnormal cell growth and development, ultimately ensuring cellular homeostasis. The activity of the BAX protein is tightly regulated by a variety of factors, including interactions with other proteins, post-translational modifications, and subcellular localization. Dysregulation of BAX activity can have serious consequences, leading to various diseases such as cancer, neurodegenerative disorders, and autoimmune diseases.
