NUP93 Antibody / Nuclear pore complex protein Nup93, Rabbit, Polyclonal
Biozol Catalog Number:
NSJ-FY12199
Supplier Catalog Number:
FY12199
Alternative Catalog Number:
NSJ-FY12199
Manufacturer:
NSJ Bioreagents
Host:
Rabbit
Category:
Antikörper
Application:
ELISA, FACS, ICC, IHC, IP, WB
Species Reactivity:
Human, Mouse, Rat
Immunogen:
E.coli-derived human NUP93 recombinant protein (Position: M1-Q677) was used as the immunogen for the NUP93 antibody.
NUP93 antibody detects Nuclear pore complex protein Nup93, encoded by the NUP93 gene on chromosome 16p13.11. NUP93 antibody is widely used to study nucleocytoplasmic transport, nuclear pore structure, and gene regulation. NUP93 is a core scaffold nucleoporin essential for assembly and function of the nuclear pore complex (NPC). It contributes to selective transport of macromolecules between the nucleus and cytoplasm, maintaining nuclear integrity and regulating gene expression. NUP93 expression is ubiquitous, consistent with its fundamental role in cell viability.Structurally, NUP93 is a ~93 kDa protein with coiled-coil domains that mediate interactions with other nucleoporins. It forms part of the inner ring of the NPC, interacting with NUP205, NUP188, and NUP62. These associations stabilize the pore scaffold and provide docking sites for transport factors. Mutations in NUP93 disrupt NPC assembly, impairing nuclear transport and transcriptional regulation.Functionally, NUP93 regulates nuclear transport by forming the selective barrier that allows import of nuclear proteins and export of RNA. It also participates in mitosis, where disassembly and reassembly of nuclear pores are tightly controlled. NUP93 influences chromatin organization and transcription by anchoring regulatory proteins at the nuclear periphery. Knockdown of NUP93 leads to nuclear transport defects, growth arrest, and apoptosis. Researchers use NUP93 antibody to explore nuclear transport, chromatin regulation, and nuclear architecture.Clinically, NUP93 mutations are linked to steroid-resistant nephrotic syndrome, a kidney disorder characterized by proteinuria and renal failure. Deficiency disrupts nuclear pore assembly in podocytes, impairing kidney function. NUP93 has also been associated with developmental abnormalities and cancer, where altered nuclear transport contributes to oncogenesis. NSJ Bioreagents provides NUP93 antibody as a reagent for nuclear transport and disease-related studies.Experimentally, NUP93 antibody is applied in western blotting to detect the ~93 kDa protein, in immunofluorescence microscopy to visualize nuclear pores, and in immunohistochemistry to assess tissue distribution. Immunoprecipitation with NUP93 antibody isolates nuclear pore complexes, supporting biochemical studies of transport machinery.
