A recombinant protein fragment from the interior region of human Als2Cr2 was used as the immunogen for this antibody.
Als2Cr2, also called STE20-related kinase adapter protein beta (STRAD beta) and ILPIP, is a serine/threonine protein kinase encoded by the STRADB gene, discovered as an XIAP interacting protein. It is a mediator of the XIAP/TAK1 activation of the JNK1 pathway, an apoptosis inhibition mechanism independent of XIAP inhibition of caspases. Alone, it only moderately activates JNKs, but its interaction with XIAP/TAK1 induces a much stronger activation of JNK1, protecting against Caspase 1- or Fas-induced apoptosis.
0.5 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Formula:
1X PBS, pH 7.4
Target:
Als2Cr2
Antibody Type:
Primary Antibody
Application Dilute:
Western blot: 5-10ug/ml
Application Notes:
Provided assay concentrations are suggestions only, Als2Cr2 antibody titration may be required for optimal results. This antibody will detect the 418 (ILPIP alpha) and 280 (ILPIP beta) amino acid isoforms.
Western blot testing of human samples with Als2Cr2 antibody at 6ug/ml.
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