SIN1 Antibody / SAPK interacting protein 1 / MAPKAP1, Rabbit, Polyclonal

Product Overview

• Article Name: SIN1 Antibody / SAPK interacting protein 1 / MAPKAP1, Rabbit, Polyclonal
• Biozol Catalog Number: NSJ-N1067-25UG
• Supplier Catalog Number: N1067-25UG
• Alternative Catalog Number: NSJ-N1067-25UG
• Manufacturer: NSJ Bioreagents
• Host: Rabbit
• Category: Antikörper
• Application: WB
• Species Reactivity: Canine, Human, Mouse, Rat
• Immunogen: A recombinant protein fragment from the C-terminal region of human SIN1 was used as the immunogen for this antibody.

Product Description

mTOR, or Mammalian target of rapamycin, a large protein kinase, is a regulator of cell growth and survival via its mTORC1 (mTOR + GBL + Raptor) and mTORC2 (mTOR + GBL + SIN1 + Rictor) complexes. SIN1 is an essential component of mTORC2, which activates Akt by phosphorylating Ser473. Phosphorylation of SIN1 at Thr86/398 causes its dissociation from the mTORC2 complex, inhibiting mTORC2s kinase activity.

Product Properties

• Clonality: Polyclonal
• Concentration: 0.5 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
• Isotype: Rabbit IgG
• NCBI: 79109
• Buffer: 1X PBS, pH 7.4
• Purity: Protein A purified antibody
• Form: 0.5 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
• Formula: 1X PBS, pH 7.4
• Target: SIN1
• Antibody Type: Primary Antibody

Application Notes

• Application Dilute: Western blot: 1-3ug/ml
• Application Notes: Provided assay concentrations are suggestions only, SIN1 antibody titration may be required for optimal results.

Images

Western blot testing of human samples with SIN1 antibody at 1ug/ml.