JAB1 Antibody / Jun activation domain-binding protein 1 / COPS5, Rabbit, Polyclonal
Biozol Catalog Number:
NSJ-R32297
Supplier Catalog Number:
R32297
Alternative Catalog Number:
NSJ-R32297
Manufacturer:
NSJ Bioreagents
Host:
Rabbit
Category:
Antikörper
Application:
FACS, IF, IHC-P, IP, WB
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Amino acids 8-334 of human JAB1 were used as the immunogen for the JAB1 antibody.
COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis), also known as COPS5 or JAB1, is a gene conserved from humans to Saccharomyces cerevisiae. It is a member of the MOV34 family. COPS5 is mapped to 8q13.1. The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. COPS5 can interact with the cytoplasmic domain of the beta-2 subunit of the alpha-L/beta-2 integrin LFA1, and it is the only protein demonstrated to interact with MIF. COPS5, VHL, and TRC8 proteins appear to be linked both physically and functionally, and all 3 may participate in the development of kidney cancer. In addition to that, COPS5 is an essential cofactor for the apoptotic function of E2F1.
Clonality:
Polyclonal
Concentration:
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Purity:
Antigen affinity
Form:
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Target:
JAB1
Antibody Type:
Primary Antibody
Application Dilute:
Western blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 2-5ug/ml,Immunofluorescence: 5ug/ml,Immunoprecipitation: 2ug per 500ug of lysate,Flow cytometry: 1-3ug/million cells
Application Notes:
Optimal dilution of the JAB1 antibody should be determined by the researcher.
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